Ontology highlight
ABSTRACT:
SUBMITTER: Wojton J
PROVIDER: S-EPMC4259431 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Wojton Jeffrey J Meisen Walter Hans WH Jacob Naduparambil K NK Thorne Amy Haseley AH Hardcastle Jayson J Denton Nicholas N Chu Zhengtao Z Dmitrieva Nina N Marsh Rachel R Van Meir Erwin G EG Kwon Chang-Hyuk CH Chakravarti Arnab A Qi Xiaoyang X Kaur Balveen B
Oncotarget 20141001 20
SapC-DOPS is a novel nanotherapeutic that has been shown to target and induce cell death in a variety of cancers, including glioblastoma (GBM). GBM is a primary brain tumor known to frequently demonstrate resistance to apoptosis-inducing therapeutics. Here we explore the mode of action for SapC-DOPS in GBM, a treatment being developed by Bexion Pharmaceuticals for clinical testing in patients. SapC-DOPS treatment was observed to induce lysosomal dysfunction of GBM cells characterized by decrease ...[more]