Ontology highlight
ABSTRACT:
SUBMITTER: Huertas-Martinez J
PROVIDER: S-EPMC4259434 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Huertas-Martínez Juan J Rello-Varona Santiago S Herrero-Martín David D Barrau Ignasi I García-Monclús Silvia S Sáinz-Jaspeado Miguel M Lagares-Tena Laura L Núñez-Álvarez Yaiza Y Mateo-Lozano Silvia S Mora Jaume J Roma Josep J Toran Nuria N Moran Sebastian S López-Alemany Roser R Gallego Soledad S Esteller Manel M Peinado Miguel A MA Del Muro Xavier García XG Tirado Oscar M OM
Oncotarget 20141001 20
Rhabdomyosarcoma is the most common soft tissue sarcoma of childhood and adolescence. Despite advances in therapy, patients with histological variant of rhabdomyosarcoma known as alveolar rhabdomyosarcoma (ARMS) have a 5-year survival of less than 30%. Caveolin-1 (CAV1), encoding the structural component of cellular caveolae, is a suggested tumor suppressor gene involved in cell signaling. In the present study we report that compared to other forms of rhabdomyosarcoma (RMS) CAV1 expression is ei ...[more]