Ontology highlight
ABSTRACT:
SUBMITTER: Wang CY
PROVIDER: S-EPMC4259441 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Wang Chih-Ya CY Liou Jing-Ping JP Tsai An-Chi AC Lai Mei-Jung MJ Liu Yi-Min YM Lee Hsueh-Yun HY Wang Jing-Chi JC Pan Shiow-Lin SL Teng Che-Ming CM
Oncotarget 20141001 20
Tissue inhibitors of metalloproteinases 3 (TIMP3) were originally characterized as inhibitors of matrix metalloproteinases (MMPs), acting as potent antiangiogenic proteins. In this study, we demonstrated that the arylsulfonamide derivative MPT0G013 has potent antiangiogenic activities in vitro and in vivo viainducing TIMP3 expression. Treatments with MPT0G013 significantly inhibited endothelial cell functions, such as cell proliferation, migration, and tube formation, as well as induced p21 and ...[more]