Next-generation sequencing of the mitochondrial genome and association with IgA nephropathy in a renal transplant population.
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ABSTRACT:
SUBMITTER: Douglas AP
PROVIDER: S-EPMC4260226 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Next-generation sequencing of the mitochondrial genome and association with IgA nephropathy in a renal transplant population.
Douglas Adam P AP Vance Dwaine R DR Kenny Elaine M EM Morris Derek W DW Maxwell Alexander P AP McKnight Amy Jayne AJ
Scientific reports 20141209
Kidneys are highly aerobic organs that are critically dependent on the normal functioning of mitochondria. Genetic variations disrupting mitochondrial function are associated with multifactorial disorders including kidney disease. This study sequenced the entire mitochondrial genome in a renal transplant cohort of 64 individuals, using next-generation sequencing, to evaluate the association of genetic variants with IgA nephropathy and end-stage renal disease (ESRD, n = 100). ...[more]
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