Ontology highlight
ABSTRACT:
SUBMITTER: Han YF
PROVIDER: S-EPMC4260354 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Han Yong-Feng YF Dou Kun K Ma Ze-Yang ZY Zhang Su-Wei SW Huang Huan-Wei HW Li Lin L Cai Tao T Chen She S Zhu Jian-Kang JK He Xin-Jian XJ
Cell research 20141125 12
The SU(VAR)3-9-like histone methyltransferases usually catalyze repressive histone H3K9 methylation and are involved in transcriptional gene silencing in eukaryotic organisms. We identified a putative SU(VAR)3-9-like histone methyltransferase SUVR2 by a forward genetic screen and demonstrated that it is involved in transcriptional gene silencing at genomic loci targeted by RNA-directed DNA methylation (RdDM). We found that SUVR2 has no histone methyltransferase activity and the conserved catalyt ...[more]