Ontology highlight
ABSTRACT:
SUBMITTER: Montague MJ
PROVIDER: S-EPMC4260561 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Montague Michael J MJ Li Gang G Gandolfi Barbara B Khan Razib R Aken Bronwen L BL Searle Steven M J SM Minx Patrick P Hillier LaDeana W LW Koboldt Daniel C DC Davis Brian W BW Driscoll Carlos A CA Barr Christina S CS Blackistone Kevin K Quilez Javier J Lorente-Galdos Belen B Marques-Bonet Tomas T Alkan Can C Thomas Gregg W C GW Hahn Matthew W MW Menotti-Raymond Marilyn M O'Brien Stephen J SJ Wilson Richard K RK Lyons Leslie A LA Murphy William J WJ Warren Wesley C WC
Proceedings of the National Academy of Sciences of the United States of America 20141110 48
Little is known about the genetic changes that distinguish domestic cat populations from their wild progenitors. Here we describe a high-quality domestic cat reference genome assembly and comparative inferences made with other cat breeds, wildcats, and other mammals. Based upon these comparisons, we identified positively selected genes enriched for genes involved in lipid metabolism that underpin adaptations to a hypercarnivorous diet. We also found positive selection signals within genes underl ...[more]