Ontology highlight
ABSTRACT:
SUBMITTER: Young ME
PROVIDER: S-EPMC4260630 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Young Martin E ME Brewer Rachel A RA Peliciari-Garcia Rodrigo A RA Collins Helen E HE He Lan L Birky Tana L TL Peden Bradley W BW Thompson Emily G EG Ammons Billy-Joe BJ Bray Molly S MS Chatham John C JC Wende Adam R AR Yang Qinglin Q Chow Chi-Wing CW Martino Tami A TA Gamble Karen L KL
Journal of biological rhythms 20140801 4
Circadian clocks are cell autonomous, transcriptionally based, molecular mechanisms that confer the selective advantage of anticipation, enabling cells/organs to respond to environmental factors in a temporally appropriate manner. Critical to circadian clock function are 2 transcription factors, CLOCK and BMAL1. The purpose of the present study was to reveal novel physiologic functions of BMAL1 in the heart, as well as to determine the pathologic consequences of chronic disruption of this circad ...[more]