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Sequential Sonagashira and Larock indole synthesis reactions in a general strategy to prepare biologically active ?-carboline-containing alkaloids.
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ABSTRACT:
SUBMITTER: Pan X
PROVIDER: S-EPMC4260633 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Publications
Sequential Sonagashira and Larock indole synthesis reactions in a general strategy to prepare biologically active β-carboline-containing alkaloids.
Organic letters 20141113 23
A general synthetic approach to β-carboline-containing alkaloids was developed. Two consecutive palladium-mediated processes, a Sonagashira coupling and a Larock indole annulation reaction, are central to the method. The scope of the approach was investigated and found to be amenable for constructing a variety of biologically significant natural products and also for preparing substituted analogues for optimization and analysis of their biological properties. ...[more]