Phylogenetic analysis and evolutionary origins of DNA polymerase X-family members.
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ABSTRACT:
SUBMITTER: Bienstock RJ
PROVIDER: S-EPMC4260717 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Publications
Phylogenetic analysis and evolutionary origins of DNA polymerase X-family members.
Bienstock Rachelle J RJ Beard William A WA Wilson Samuel H SH
DNA repair 20140809
Mammalian DNA polymerase (pol) β is the founding member of a large group of DNA polymerases now termed the X-family. DNA polymerase β has been kinetically, structurally, and biologically well characterized and can serve as a phylogenetic reference. Accordingly, we have performed a phylogenetic analysis to understand the relationship between pol β and other members of the X-family of DNA polymerases. The bacterial X-family DNA polymerases, Saccharomyces cerevisiae pol IV, and four mammalian X-fam ...[more]
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