Docosahexaenoic acid induces the degradation of HPV E6/E7 oncoproteins by activating the ubiquitin-proteasome system.
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ABSTRACT:
SUBMITTER: Jing K
PROVIDER: S-EPMC4260735 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
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Docosahexaenoic acid induces the degradation of HPV E6/E7 oncoproteins by activating the ubiquitin-proteasome system.
Jing K K Shin S S Jeong S S Kim S S Song K-S KS Park J-H JH Heo J-Y JY Seo K-S KS Park S-K SK Kweon G-R GR Wu T T Park J-I JI Lim K K
Cell death & disease 20141113
The oncogenic human papillomavirus (HPV) E6/E7 proteins are essential for the onset and maintenance of HPV-associated malignancies. Here, we report that activation of the cellular ubiquitin-proteasome system (UPS) by the omega-3 fatty acid, docosahexaenoic acid (DHA), leads to proteasome-mediated degradation of E6/E7 viral proteins and the induction of apoptosis in HPV-infected cancer cells. The increases in UPS activity and degradation of E6/E7 oncoproteins were associated with DHA-induced over ...[more]
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