Ontology highlight
ABSTRACT:
SUBMITTER: Sakadzic S
PROVIDER: S-EPMC4260810 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Nature communications 20141208
What is the organization of cerebral microvascular oxygenation and morphology that allows adequate tissue oxygenation at different activity levels? We address this question in the mouse cerebral cortex using microscopic imaging of intravascular O2 partial pressure and blood flow combined with numerical modelling. Here we show that parenchymal arterioles are responsible for 50% of the extracted O2 at baseline activity, and the majority of the remaining O2 exchange takes place within the first few ...[more]