Ontology highlight
ABSTRACT:
SUBMITTER: Soliman MA
PROVIDER: S-EPMC4260967 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Science signaling 20140218 313
Adaptor proteins link surface receptors to intracellular signaling pathways and potentially control the way cells respond to nutrient availability. Mice deficient in p66Shc, the most recently evolved isoform of the Shc1 adaptor proteins and a mediator of receptor tyrosine kinase signaling, display resistance to diabetes and obesity. Using quantitative mass spectrometry, we found that p66Shc inhibited glucose metabolism. Depletion of p66Shc enhanced glycolysis and increased the allocation of gluc ...[more]