Genetic variation: effect on prostate cancer.
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ABSTRACT:
SUBMITTER: Sissung TM
PROVIDER: S-EPMC4260983 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Publications
Genetic variation: effect on prostate cancer.
Sissung Tristan M TM Price Douglas K DK Del Re Marzia M Ley Ariel M AM Giovannetti Elisa E Figg William D WD Danesi Romano R
Biochimica et biophysica acta 20140906 2
The crucial role of androgens in the development of prostate cancer is well established. The aim of this review is to examine the role of constitutional (germline) and tumor-specific (somatic) polymorphisms within important regulatory genes of prostate cancer. These include genes encoding enzymes of the androgen biosynthetic pathway, the androgen receptor gene, genes that encode proteins of the signal transduction pathways that may have a role in disease progression and survival, and genes invol ...[more]
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