Genetic variants within obesity-related genes are associated with tumor recurrence in patients with stages II/III colon cancer.

ABSTRACT:

Objective

Obesity is an established risk factor for colorectal cancer (CRC) incidence and it is also linked to CRC recurrence and survival. Polymorphisms located in obesity-related genes are associated with an increased risk of developing several cancer types including CRC. We evaluated whether single-nucleotide polymorphisms in obesity-related genes may predict tumor recurrence in colon cancer patients.

Materials and methods

Genotypes were obtained from germline DNA from 207 patients with stage II or III colon cancer at the Norris Comprehensive Cancer Center. Nine polymorphisms in eight obesity-related genes (PPAR, LEP, NFKB, CD36, DRG1, NGAL, REGIA, and DSCR1) were evaluated. The primary endpoint of the study was the 3-year recurrence rate. Positive associations were also

SUBMITTER: Sebio A 

PROVIDER: S-EPMC4260998 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature