Ontology highlight
ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC4261066 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Wang J J Mikse O O Liao R G RG Li Y Y Tan L L Janne P A PA Gray N S NS Wong K-k KK Hammerman P S PS
Oncogene 20140609 17
Somatic alterations of fibroblast growth factor receptors (FGFRs) have been described in a wide range of malignancies. A number of anti-FGFR therapies are currently under investigation in clinical trials for subjects with FGFR gene amplifications, mutations and translocations. Here, we develop cell line models of acquired resistance to FGFR inhibition by exposure of cell lines harboring FGFR3 gene amplification and translocation to the selective FGFR inhibitor BGJ398 and multitargeted FGFR inhib ...[more]