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Intestinal colonization by a Lachnospiraceae bacterium contributes to the development of diabetes in obese mice.

ABSTRACT: The aim of the present study was to identify bacteria that may contribute to the onset of metabolic dysfunctions. We isolated and identified a candidate bacterium belonging to Lachnospiraceae (strain AJ110941) in the feces of hyperglycemic obese mice. The colonization of germ-free ob/ob mice by AJ110941 induced significant increases in fasting blood glucose levels as well as liver and mesenteric adipose tissue weights, and decreases in plasma insulin levels and HOMA-? values. These results indicated that the specific gut commensal bacterium AJ110941 influenced the development of obesity and diabetes in ob/ob mice with genetic susceptibility for obesity.

SUBMITTER: Kameyama K

PROVIDER: S-EPMC4262368 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Intestinal colonization by a Lachnospiraceae bacterium contributes to the development of diabetes in obese mice.

Kameyama Keishi K Itoh Kikuji K

Microbes and environments 20141004 4

The aim of the present study was to identify bacteria that may contribute to the onset of metabolic dysfunctions. We isolated and identified a candidate bacterium belonging to Lachnospiraceae (strain AJ110941) in the feces of hyperglycemic obese mice. The colonization of germ-free ob/ob mice by AJ110941 induced significant increases in fasting blood glucose levels as well as liver and mesenteric adipose tissue weights, and decreases in plasma insulin levels and HOMA-β values. These results indic ...[more]

PMID: 25283478

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