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HIV latency. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells.


ABSTRACT: The persistence of HIV-infected cells in individuals on suppressive combination antiretroviral therapy (cART) presents a major barrier for curing HIV infections. HIV integrates its DNA into many sites in the host genome; we identified 2410 integration sites in peripheral blood lymphocytes of five infected individuals on cART. About 40% of the integrations were in clonally expanded cells. Approximately 50% of the infected cells in one patient were from a single clone, and some clones persisted for many years. There were multiple independent integrations in several genes, including MKL2 and BACH2; many of these integrations were in clonally expanded cells. Our findings show that HIV integration sites can play a critical role in expansion and persistence of HIV-infected cells.

SUBMITTER: Maldarelli F 

PROVIDER: S-EPMC4262401 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature

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HIV latency. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells.

Maldarelli F F   Wu X X   Su L L   Simonetti F R FR   Shao W W   Hill S S   Spindler J J   Ferris A L AL   Mellors J W JW   Kearney M F MF   Coffin J M JM   Hughes S H SH  

Science (New York, N.Y.) 20140626 6193


The persistence of HIV-infected cells in individuals on suppressive combination antiretroviral therapy (cART) presents a major barrier for curing HIV infections. HIV integrates its DNA into many sites in the host genome; we identified 2410 integration sites in peripheral blood lymphocytes of five infected individuals on cART. About 40% of the integrations were in clonally expanded cells. Approximately 50% of the infected cells in one patient were from a single clone, and some clones persisted fo  ...[more]

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