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Maternal blood and hair manganese concentrations, fetal growth, and length of gestation in the ISA cohort in Costa Rica.

ABSTRACT: Animal studies have shown that both deficiency and excess manganese (Mn) may result in decreased fetal size and weight, but human studies have reported inconsistent results.We examined the association of blood and hair Mn concentrations measured at different times during pregnancy with fetal growth among term births and length of gestation in a cohort of 380 mother-infant pairs living near banana plantations aerially sprayed with Mn-containing fungicides in Costa Rica. We used linear regression and generalized additive models to test for linear and nonlinear associationsMean (± SD) blood Mn concentration was 24.4 ± 6.6 ?g/L and geometric mean (geometric SD) hair Mn concentration was 1.8 (3.2) ?g/g. Hair Mn concentrations during the second and third trimesters of gestation were positively related to infant chest circumference (? for 10-fold increase = 0.62 cm; 95% CI: 0.16, 1.08; and ? = 0.55 cm; 95% CI: -0.16, 1.26, respectively). Similarly, average maternal hair Mn concentrations during pregnancy were associated with increased chest circumference (? for 10-fold increase = 1.19 cm; 95% CI: 0.43, 1.95) in infants whose mothers did not have gestational anemia, but not in infants of mothers who had gestational anemia (? = 0.39 cm; 95% CI: -0.32, 1.10; pINT=0.14). All these associations were linear. Blood Mn concentrations did not show consistent linear nor nonlinear relationships with any of the birth outcomesMn plays an important role in fetal development, but the extent to which environmental exposures may cause adverse health effects to the developing fetus is not well understood. Among women living near banana plantations in Costa Rica, we did not observe linear or nonlinear associations of Mn concentrations with lowered birth weight or head circumference, as reported in previous studies. However, we did find positive linear associations between maternal hair Mn concentrations during pregnancy and infant chest circumference.

SUBMITTER: Mora AM

PROVIDER: S-EPMC4262687 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature

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Maternal blood and hair manganese concentrations, fetal growth, and length of gestation in the ISA cohort in Costa Rica.

Mora Ana M AM van Wendel de Joode Berna B Mergler Donna D Córdoba Leonel L Cano Camilo C Quesada Rosario R Smith Donald R DR Menezes-Filho José A JA Eskenazi Brenda B

Environmental research 20141120

<h4>Background</h4>Animal studies have shown that both deficiency and excess manganese (Mn) may result in decreased fetal size and weight, but human studies have reported inconsistent results.<h4>Methods</h4>We examined the association of blood and hair Mn concentrations measured at different times during pregnancy with fetal growth among term births and length of gestation in a cohort of 380 mother-infant pairs living near banana plantations aerially sprayed with Mn-containing fungicides in Cos ...[more]

PMID: 25460620

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Project description:BackgroundOnly few studies have compared environmental pesticide air concentrations with specific urinary metabolites to evaluate pathways of exposure. Therefore, we compared pyrimethanil and chlorpyrifos concentrations in air with urinary 4-hydroxypyrimethanil (OHP, metabolite of pyrimethanil) and 3,5,6-trichloro-2-pyridinol (TCPy, metabolite of chlorpyrifos) among pregnant women from the Infant's Environmental Health Study (ISA) in Matina County, Costa Rica.MethodsDuring pregnancy, we obtained repeat urinary samples from 448 women enrolled in the ISA study. We extrapolated pyrimethanil and chlorpyrifos concentrations measured with passive air samplers (PAS) (n = 48, from 12 schools), across space and time using a Bayesian spatiotemporal model. We subsequently compared these concentrationswith urinary OHP and TCPy in 915 samples from 448 women, usingseparatemixed models andconsidering several covariables.ResultsA 10% increase in air pyrimethanil (ng/m3) was associated with a 5.7% (95% confidence interval (CI 4.6, 6.8) increase in OHP (μg/L). Women living further from banana plantations had lower OHP: -0.7% (95% CI -1.2, -0.3) for each 10% increase in distance (meters) as well as women who ate rice and beans ≥15 times a week -23% (95% CI -38, -4). In addition, each 1 ng/m3 increase in chlorpyrifos in air was associated with a 1.5% (95% CI 0.2, 2.8) increase in TCPy (μg/L), and women working in agriculture tended to have increased TCPy (21%, 95% CI -2, 49).ConclusionThe Bayesian spatiotemporal models were useful to estimate pyrimethanil and chlorpyrifos air concentrations across space and time. Our results suggest inhalation of pyrimethanil and chlorpyrifos is a pathway of environmental exposure. PAS seems a useful technique to monitor environmental current-use pesticide exposures. For future studies, we recommend increasing the number of locations of environmental air measurements, obtaining all air and urine measurements during the same month, and, ideally, including dermal exposure estimates as well.

Project description:Global bottled water consumption has largely increased (14.35 billion gallons in 2020) [1], [2], [3], [4], [5] during the last decade since consumers are demanding healthier and safer forms of rehydration. Bottled water sources are normally labeled as mountainous and pristine mineral springs (fed by rainfall and snow/glacier melting processes), deep groundwater wells or industrial purified water. The advent of numerous international and national-based bottled water brands has simultaneously raised a worldwide awareness related to the water source and chemical content traceability [6]. Here, we present the first database of stable isotope compositions and reported chemical concentrations from imported and national-based bottled waters in Costa Rica. In total, 45 bottled waters produced in Costa Rica and 31 imported from USA, Europe, Oceania, and other countries of Central America were analyzed for δ18O, δ2H, and d-excess. Chemical compositions were obtained from available bottle labels. National-based bottle waters ranged from -2.47‰ to -10.65‰ in δ18O and from -10.4‰ to -78.0‰ in δ2H, while d-excess varied from +4.2‰ up to +17.0‰. International bottle waters ranged between -2.21‰ and -11.03‰ in δ18O and from -11.3‰ up to -76.0‰ in δ2H, while d-excess varied from +5.0‰ up to +19.1‰. In Costa Rica, only 19% of the brands reported chemical parameters such as Na+, K+, Ca+2, Mg+2, F-, Cl-, NO3 -, SO4 -2, CO3 -2, SiO2, dry residue, and pH; whereas 27% of the international products reported similar parameters. The absence of specific geographic coordinates or water source origin limited a spatial analysis to validate bottled water isotope compositions versus available isoscapes in Costa Rica [7]. This database highlights the potential and relevance of the use of water stable isotope compositions to improve the traceability of bottled water sources and the urgent need of more robust legislation in order to provide detailed information (i.e., water source, chemical composition, purification processes) to the final consumers.

Dataset Information

Maternal blood and hair manganese concentrations, fetal growth, and length of gestation in the ISA cohort in Costa Rica.

Publications

Maternal blood and hair manganese concentrations, fetal growth, and length of gestation in the ISA cohort in Costa Rica.

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