MicroRNAs: modulators of cell identity, and their applications in tissue engineering.
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ABSTRACT:
SUBMITTER: Ribeiro AO
PROVIDER: S-EPMC4262937 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
MicroRNAs: modulators of cell identity, and their applications in tissue engineering.
Ribeiro Amanda O AO Schoof Claudia R G CR Izzotti Alberto A Pereira Lygia V LV Vasques Luciana R LR
MicroRNA (Shariqah, United Arab Emirates) 20140101 1
MicroRNAs post-transcriptionally regulate the expression of approximately 60% of the mammalian genes, and have an important role in maintaining the differentiated state of somatic cells through the expression of unique tissuespecific microRNA sets. Likewise, the stemness of pluripotent cells is also sustained by embryonic stem cell-enriched microRNAs, which regulate genes involved in cell cycle, cell signaling and epigenetics, among others. Thus, microRNAs work as modulator molecules that ensure ...[more]
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