Ontology highlight
ABSTRACT:
SUBMITTER: Kajava AV
PROVIDER: S-EPMC4262963 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Kajava Andrey V AV Klopffleisch Karsten K Chen Shuhua S Hofmann Kay K
Scientific reports 20141211
The Rip homotypic interaction motif (RHIM) is a short, non-globular sequence stretch that mediates a key interaction of mammalian necroptosis signaling. In order to understand its unusual oligomerization properties, we set out to trace the evolutionary origins of the RHIM motif by identifying distantly related protein motifs that might employ the same binding mode. The RHIM motif was found to be related to the prion-forming domain of the HET-s protein, which oligomerizes by forming structurally ...[more]