Ontology highlight
ABSTRACT:
SUBMITTER: Yu K
PROVIDER: S-EPMC4263227 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Yu Kai K Zhang Han H Wheeler William W Horne Hisani N HN Chen Jinbo J Figueroa Jonine D JD
Biostatistics (Oxford, England) 20140723 1
One common strategy for detecting disease-associated genetic markers is to compare the genotype distributions between cases and controls, where cases have been diagnosed as having the disease condition. In a study of a complex disease with a heterogeneous etiology, the sampled case group most likely consists of people having different disease subtypes. If we conduct an association test by treating all cases as a single group, we maximize our chance of finding genetic risk factors with a homogene ...[more]