Ontology highlight
ABSTRACT:
SUBMITTER: Dzialo MC
PROVIDER: S-EPMC4263273 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Dzialo Maria C MC Travaglini Kyle J KJ Shen Sean S Loo Joseph A JA Clarke Steven G SG
Biochemical and biophysical research communications 20141115 3-4
The elongation factors of Saccharomyces cerevisiae are extensively methylated, containing a total of ten methyllysine residues. Elongation factor methyltransferases (Efm1, Efm2, Efm3, and Efm4) catalyze at least four of these modifications. Here we report the identification of a new type of protein lysine methyltransferase, Efm5 (Ygr001c), which was initially classified as N6-adenine DNA methyltransferase-like. Efm5 is required for trimethylation of Lys-79 on EF1A. We directly show the loss of t ...[more]