Ontology highlight
ABSTRACT:
SUBMITTER: Hilpert M
PROVIDER: S-EPMC4264042 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Hilpert Morgane M Legrand Céline C Bluteau Dominique D Balayn Natalie N Betems Aline A Bluteau Olivier O Villeval Jean-Luc JL Louache Fawzia F Gonin Patrick P Debili Najet N Plo Isabelle I Vainchenker William W Gilles Laure L Raslova Hana H
Stem cell reports 20141120 6
Hematopoietic stem cells (HSCs) are characterized by the capacity for self-renewal and the ability to reconstitute the entire hematopoietic compartment. Thrombopoietin maintains adult HSCs in a quiescent state through the induction of cell cycle inhibitors p57(Kip2) and p19(INK4d). Using the p19(INK4d-/-) mouse model, we investigated the role of p19(INK4d) in basal and stress-induced hematopoiesis. We demonstrate that p19(INK4d) is involved in the regulation of HSC quiescence by inhibition of th ...[more]