Ontology highlight
ABSTRACT:
SUBMITTER: Lewin J
PROVIDER: S-EPMC4264446 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Lewin J J Khamly K K KK Young R J RJ Mitchell C C Hicks R J RJ Toner G C GC Ngan S Y K SY Chander S S Powell G J GJ Herschtal A A Te Marvelde L L Desai J J Choong P F M PF Choong P F M PF Stacker S A SA Achen M G MG Ferris N N Fox S S Slavin J J Thomas D M DM
British journal of cancer 20141016 12
<h4>Background</h4>Preoperative radiotherapy (RT) is commonly used to treat localised soft-tissue sarcomas (STS). Hypoxia is an important determinant of radioresistance. Whether antiangiogenic therapy can 'normalise' tumour vasculature, thereby improving oxygenation, remains unknown.<h4>Methods</h4>Two cohorts were prospectively enrolled. Cohort A evaluated the implications of hypoxia in STS, using the hypoxic tracer (18)F-azomycin arabinoside (FAZA-PET). In cohort B, sunitinib was added to preo ...[more]