H-NS is a repressor of major virulence gene loci in Vibrio parahaemolyticus.
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ABSTRACT:
SUBMITTER: Sun F
PROVIDER: S-EPMC4264476 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
H-NS is a repressor of major virulence gene loci in Vibrio parahaemolyticus.
Sun Fengjun F Zhang Yiquan Y Qiu Yefeng Y Yang Huiying H Yang Wenhui W Yin Zhe Z Wang Jie J Yang Ruifu R Xia Peiyuan P Zhou Dongsheng D
Frontiers in microbiology 20141212
Vibrio parahaemolyticus, a leading cause of seafood-associated diarrhea and gastroenteritis, harbors three major virulence gene loci T3SS1, Vp-PAI (T3SS1+tdh2) and T6SS2. As showing in this study, the nucleoid-associated DNA-binding regulator H-NS binds to multiple promoter-proximal regions in each of the above three loci to repress their transcription, and moreover H-NS inhibits the cytotoxicitiy, enterotoxicity, hemolytic activity, and mouse lethality of V. parahaemolyticus. H-NS appears to ac ...[more]
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