Ontology highlight
ABSTRACT:
SUBMITTER: Bloch SE
PROVIDER: S-EPMC4264569 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Bloch Sarah E SE Schmidt-Dannert Claudia C
Chembiochem : a European journal of chemical biology 20140909 16
Hydroxycinnamic acid esters (HCEs) are widely-distributed phenylpropanoid-derived plant natural products. Rosmarinic acid (RA), the most well-known HCE, shows promise as a treatment for cancer and neurological disorders. In contrast to extraction from plant material or plant cell culture, microbial production of HCEs could be a sustainable, controlled means of production. Through the overexpression of a six-enzyme chimeric bacterial and plant pathway, we show the de novo biosynthesis of RA, and ...[more]