Ontology highlight
ABSTRACT:
SUBMITTER: Porro A
PROVIDER: S-EPMC4264578 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Nature communications 20141031
Telomere deprotection occurs during tumorigenesis and aging upon telomere shortening or loss of the telomeric shelterin component TRF2. Deprotected telomeres undergo changes in chromatin structure and elicit a DNA damage response (DDR) that leads to cellular senescence. The telomeric long noncoding RNA TERRA has been implicated in modulating the structure and processing of deprotected telomeres. Here, we characterize the human TERRA transcriptome at normal and TRF2-depleted telomeres and demonst ...[more]