Ontology highlight
ABSTRACT:
SUBMITTER: Banerjee K
PROVIDER: S-EPMC4264680 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Nature communications 20141210
Regulation of tyrosine hydroxylase gene (Th) transcription is critical for specifying and maintaining the dopaminergic neuronal phenotype. Here we define a molecular regulatory mechanism for Th transcription conserved in tetrapod vertebrates. We show that heterogeneous nuclear ribonucleoprotein (hnRNP) K is a transactivator of Th transcription. It binds to previously unreported and evolutionarily conserved G:C-rich regions in the Th proximal promoter. hnRNP K directly binds to C-rich single-stra ...[more]