Cezanne (OTUD7B) regulates HIF-1? homeostasis in a proteasome-independent manner.
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ABSTRACT:
SUBMITTER: Bremm A
PROVIDER: S-EPMC4264929 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Publications
Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner.
Bremm Anja A Moniz Sonia S Mader Julia J Rocha Sonia S Komander David D
EMBO reports 20141029 12
The transcription factor HIF-1α is essential for cells to rapidly adapt to low oxygen levels (hypoxia). HIF-1α is frequently deregulated in cancer and correlates with poor patient prognosis. Here, we demonstrate that the deubiquitinase Cezanne regulates HIF-1α homeostasis. Loss of Cezanne decreases HIF-1α target gene expression due to a reduction in HIF-1α protein levels. Surprisingly, although the Cezanne-regulated degradation of HIF-1α depends on the tumour suppressor pVHL, hydroxylase and pro ...[more]
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2020-01-24 | PXD015216 | Pride