Ontology highlight
ABSTRACT:
SUBMITTER: Kosmaczewski SG
PROVIDER: S-EPMC4264930 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Kosmaczewski Sara Guckian SG Edwards Tyson James TJ Han Sung Min SM Eckwahl Matthew J MJ Meyer Benjamin Isaiah BI Peach Sally S Hesselberth Jay R JR Wolin Sandra L SL Hammarlund Marc M
EMBO reports 20141103 12
RNA ligation can regulate RNA function by altering RNA sequence, structure and coding potential. For example, the function of XBP1 in mediating the unfolded protein response requires RNA ligation, as does the maturation of some tRNAs. Here, we describe a novel in vivo model in Caenorhabditis elegans for the conserved RNA ligase RtcB and show that RtcB ligates the xbp-1 mRNA during the IRE-1 branch of the unfolded protein response. Without RtcB, protein stress results in the accumulation of unlig ...[more]