Ontology highlight
ABSTRACT:
SUBMITTER: Kandakatla N
PROVIDER: S-EPMC4265523 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Kandakatla Naresh N Ramakrishnan Geetha G
Advances in bioinformatics 20141126
Histone deacetylases 2 (HDAC2), Class I histone deacetylase (HDAC) family, emerged as an important therapeutic target for the treatment of various cancers. A total of 48 inhibitors of two different chemotypes were used to generate pharmacophore model using 3D QSAR pharmacophore generation (HypoGen algorithm) module in Discovery Studio. The best HypoGen model consists of four pharmacophore features namely, one hydrogen bond acceptor (HBA), and one hydrogen donor (HBD), one hydrophobic (HYP) and o ...[more]