Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1).
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ABSTRACT:
SUBMITTER: Fang C
PROVIDER: S-EPMC4265822 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Publications
Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1).
Fang Chao C D'Souza Brendan B Thompson Christopher F CF Clifton Matthew C MC Fairman James W JW Fulroth Ben B Leed Alison A McCarren Patrick P Wang Lili L Wang Yikai Y Feau Clementine C Kaushik Virendar K VK Palmer Michelle M Wei Guo G Golub Todd R TR Hubbard Brian K BK Serrano-Wu Michael H MH
ACS medicinal chemistry letters 20141111 12
A direct binding screen of 100 000 sp(3)-rich molecules identified a single diastereomer of a macrolactam core that binds specifically to myeloid cell leukemia 1 (MCL1). A comprehensive toolbox of biophysical methods was applied to validate the original hit and subsequent analogues and also established a binding mode competitive with NOXA BH3 peptide. X-ray crystallography of ligand bound to MCL1 reveals a remarkable ligand/protein shape complementarity that diverges from previously disclosed MC ...[more]
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