Cigarette smoking is associated with dose-dependent adverse effects on paraoxonase activity and fibrinogen in young women.

ABSTRACT:

Context

Smoking is associated with increased fibrinogen and decreased paraoxonase (PON) activity, markers of inflammation and oxidative stress, in patients with coronary artery disease.

Objective

We tested the hypothesis that the adverse effect of smoking on these biomarkers of inflammation and oxidative stress would be detectable in otherwise healthy young female habitual smokers.

Materials and methods

Thirty-eight young women participated in the study (n?=?20 habitual smokers, n?=?18 non-smokers). Fibrinogen, PON-1 activity and HDL oxidant index (HOI) were measured.

Results

Mean values of fibrinogen, PON-1 activity and log HOI were not different between the groups. Importantly, however, decreased PON-1 activity (rs?=?-0.51, p?=?0.03) and increased fibrinogen (rs?=?0.49, p?=?0.04) were significantly correlated with increasing number of cigarettes smoked per day in habitual smokers.

Discussion and conclusion

Cigarette smoking is associated with a dose-dependent adverse effect on PON-1 activity and fibrinogen in young women, which may have implications for future cardiovascular risk.

SUBMITTER: Ramanathan G 

PROVIDER: S-EPMC4266070 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature