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Chemoenzymatic synthesis of spinosyn A.

ABSTRACT: Following the biosynthesis of polyketide backbones by polyketide synthases (PKSs), post-PKS modifications result in a significantly elevated level of structural complexity that renders the chemical synthesis of these natural products challenging. We report herein a total synthesis of the widely used polyketide insecticide spinosyn?A by exploiting the prowess of both chemical and enzymatic methods. As more polyketide biosynthetic pathways are characterized, this chemoenzymatic approach is expected to become readily adaptable to streamlining the synthesis of other complex polyketides with more elaborate post-PKS modifications.

SUBMITTER: Kim HJ

PROVIDER: S-EPMC4266379 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature

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Chemoenzymatic synthesis of spinosyn A.

Kim Hak Joong HJ Choi Sei-hyun SH Jeon Byung-sun BS Kim Namho N Pongdee Rongson R Wu Qingquan Q Liu Hung-wen HW

Angewandte Chemie (International ed. in English) 20141006 49

Following the biosynthesis of polyketide backbones by polyketide synthases (PKSs), post-PKS modifications result in a significantly elevated level of structural complexity that renders the chemical synthesis of these natural products challenging. We report herein a total synthesis of the widely used polyketide insecticide spinosyn A by exploiting the prowess of both chemical and enzymatic methods. As more polyketide biosynthetic pathways are characterized, this chemoenzymatic approach is expecte ...[more]

PMID: 25287333

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