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PPAR? gene variants as predicted performance-enhancing polymorphisms in professional Italian soccer players.

ABSTRACT: BACKGROUND:The PPAR? gene encodes the peroxisome proliferator-activator receptor alpha, a central regulator of expression of other genes involved in fatty acid metabolism. The purpose of this study was to determine the prevalence of G allele of the PPAR? intron 7 G/C polymorphism (rs4253778) in professional Italian soccer players. METHODS:Sixty professional soccer players and 30 sedentary volunteers were enrolled in the study. Samples of venous blood were obtained at rest, in the morning, by conventional clinical procedures; blood serum was collected and total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides were measured. An aliquot of anticoagulant-treated blood was used to prepare genomic DNA from whole blood. The G/C polymorphic site in PPAR? intron 7 was scanned by using the PCR-RFLP (polymerase chain reaction restriction fragment length polymorphism) protocol with TaqI enzyme. RESULTS:We found variations in genotype distribution of PPAR? polymorphism between professional soccer players and sedentary volunteers. Particularly, G alleles and the GG genotype were significantly more frequent in soccer players compared with healthy controls (64% versus 48%). No significant correlations were found between lipid profile and genotype background. CONCLUSION:Previous results demonstrated an association of intron 7 G allele as well as the GG genotype in endurance athletes. Our result suggests that this is the case also in professional soccer players.

SUBMITTER: Proia P

PROVIDER: S-EPMC4266416 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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PPARα gene variants as predicted performance-enhancing polymorphisms in professional Italian soccer players.

Proia Patrizia P Bianco Antonino A Schiera Gabriella G Saladino Patrizia P Contrò Valentina V Caramazza Giovanni G Traina Marcello M Grimaldi Keith A KA Palma Antonio A Paoli Antonio A

Open access journal of sports medicine 20141208

<h4>Background</h4>The PPARα gene encodes the peroxisome proliferator-activator receptor alpha, a central regulator of expression of other genes involved in fatty acid metabolism. The purpose of this study was to determine the prevalence of G allele of the PPARα intron 7 G/C polymorphism (rs4253778) in professional Italian soccer players.<h4>Methods</h4>Sixty professional soccer players and 30 sedentary volunteers were enrolled in the study. Samples of venous blood were obtained at rest, in the ...[more]

PMID: 25525399

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Project description:The current study had two aims. The primary purpose was to examine the association between serum vitamin D levels and the ergometric evaluation of muscle strength, aerobic capacity, and speed in professional soccer players. The secondary aim was to evaluate the effects of the soccer off-season period on serum vitamin D levels.Sixty-seven Caucasian male soccer players (age 25.6 ± 6.2 and height 1.81 ± 0.08 m), members of two Greek Superleague Soccer teams and one Football-league championship team participated in this study. Exercise performance testing for the determination of squat jump (SJ), countermovement jump (CMJ), 10 (10 m) and 20 meters (20 m) sprint performance, maximal oxygen consumption (VO2max), anthropometry, and blood sampling were performed before (pre) and after (post) the six-week off-season period.Analysis of our results showed the following: (a) a significant correlations between serum vitamin D levels and performance parameters in both pre (SJ; P < 0.001, CMJ; P < 0.001, VO2max; P < 0.001, 10 m; P < 0.001, and 20 m; P < 0.001) and post (SJ; P < 0.001, CMJ; P<0.001, VO2max; P = 0.006, 10 m; P < 0.001, and 20 m; P < 0.001) experimental sessions. (b) Vitamin D concentration increased significantly (P < 0.001) following the six-week off-season period compared to baseline, while at the same time all measured performance parameters decreased (SJ; P < 0.001, CMJ; P < 0.001, 10 m; P < 0.001, 20 m; P < 0.001, VO2max; P<0.001).Our findings suggest that vitamin D levels are associated with the ergometric evaluation of muscle strength, as expressed by SJ and CMJ, sprinting capacity, and VO2max in professional soccer players, irrespective the levels of performance. Furthermore, our data reaffirm the importance of UVB on serum vitamin D levels. Moreover, reductions in exercise training stress may also have beneficial effects on vitamin D levels, suggesting a possible association of its levels and the training-induced stress. Our results indicate a possibly bidirectional interaction between soccer performance indices and vitamin D levels.

Project description:BackgroundNeurodegenerative disorders have been reported in elite athletes who participated in contact sports. The incidence of neurodegenerative disease among former professional soccer players has not been well characterized.MethodsWe conducted a retrospective cohort study to compare mortality from neurodegenerative disease among 7676 former professional soccer players (identified from databases of Scottish players) with that among 23,028 controls from the general population who were matched to the players on the basis of sex, age, and degree of social deprivation. Causes of death were determined from death certificates. Data on medications dispensed for the treatment of dementia in the two cohorts were also compared. Prescription information was obtained from the national Prescribing Information System.ResultsOver a median of 18 years, 1180 former soccer players (15.4%) and 3807 controls (16.5%) died. All-cause mortality was lower among former players than among controls up to the age of 70 years and was higher thereafter. Mortality from ischemic heart disease was lower among former players than among controls (hazard ratio, 0.80; 95% confidence interval [CI], 0.66 to 0.97; P = 0.02), as was mortality from lung cancer (hazard ratio, 0.53; 95% CI, 0.40 to 0.70; P<0.001). Mortality with neurodegenerative disease listed as the primary cause was 1.7% among former soccer players and 0.5% among controls (subhazard ratio [the hazard ratio adjusted for competing risks of death from ischemic heart disease and death from any cancer], 3.45; 95% CI, 2.11 to 5.62; P<0.001). Among former players, mortality with neurodegenerative disease listed as the primary or a contributory cause on the death certificate varied according to disease subtype and was highest among those with Alzheimer's disease (hazard ratio [former players vs. controls], 5.07; 95% CI, 2.92 to 8.82; P<0.001) and lowest among those with Parkinson's disease (hazard ratio, 2.15; 95% CI, 1.17 to 3.96; P = 0.01). Dementia-related medications were prescribed more frequently to former players than to controls (odds ratio, 4.90; 95% CI, 3.81 to 6.31; P<0.001). Mortality with neurodegenerative disease listed as the primary or a contributory cause did not differ significantly between goalkeepers and outfield players (hazard ratio, 0.73; 95% CI, 0.43 to 1.24; P = 0.24), but dementia-related medications were prescribed less frequently to goalkeepers (odds ratio, 0.41; 95% CI, 0.19 to 0.89; P = 0.02).ConclusionsIn this retrospective epidemiologic analysis, mortality from neurodegenerative disease was higher and mortality from other common diseases lower among former Scottish professional soccer players than among matched controls. Dementia-related medications were prescribed more frequently to former players than to controls. These observations need to be confirmed in prospective matched-cohort studies. (Funded by the Football Association and Professional Footballers' Association.).

Project description:BackgroundRectus femoris injuries are common among athletes, especially in kicking sports such as soccer; however, proximal rectus femoris avulsions in athletes are a relatively rare entity.Purpose/hypothesisThe purpose of this study was to describe and report the results of an original technique of surgical excision of the proximal tendon remnant followed by a muscular suture repair. Our hypothesis was that this technique limits the risk of recurrence in high-level athletes and allows for rapid recovery without loss of quadriceps strength.Study designCase series; Level of evidence, 4.MethodsOur retrospective series included 5 players aged 31.8 ± 3.9 years with acute proximal rectus femoris avulsion injuries who underwent a surgical resection of the proximal tendon between March 2012 and June 2014. Four of these players had recurrent rectus femoris injuries in the 9 months before surgery, while 1 player had surgery after a first injury. Mean follow-up was 18.2 ± 12.6 months, and minimum follow-up was 9 months. We analyzed the age, sex distribution, physical examination outcomes, type and mechanism of injury, diagnosis, treatment and complications during surgery, postoperative follow-up, and time to return to play. The Lower Extremity Functional Scale (LEFS) and Marx scores were obtained at 3-month follow-up, and isokinetic tests were performed before return to sports. A telephone interview was completed to determine the presence of recurrence at an average follow-up of 18.2 months.ResultsAt 3-month follow-up, all patients had Marx activity scores of 16 and LEFS scores of 80. Return to the previous level of play occurred at a mean of 15.8 ± 2.6 weeks after surgery, and none of the athletes suffered a recurrence. Isokinetic test results were comparable between both sides.ConclusionThe surgical treatment of proximal rectus femoris avulsions, consisting of resection of the tendinous part of the muscle, is a reliable and safe technique allowing a fast recovery in professional athletes.

Project description:BackgroundSprint performance is an essential skill to target within soccer, which can be likely achieved with a variety of methods, including different on-field training options. One such method could be heavy resisted sprint training. However, the effects of such overload on sprint performance and the related kinetic changes are unknown in a professional setting. Another unknown factor is whether violating kinematic specificity via heavy resistance will lead to changes in unloaded sprinting kinematics. We investigated whether heavy resisted sled training (HS) affects sprint performance, kinetics, sagittal plane kinematics, and spatiotemporal parameters in professional male soccer players.MethodsAfter familiarization, a nine-week training protocol and a two-week taper was completed with sprint performance and force-velocity (FV) profiles compared before and after. Out of the two recruited homogenous soccer teams (N = 32, age: 24.1 ± 5.1 years: height: 180 ± 10 cm; body-mass: 76.7 ± 7.7 kg, 30-m split-time: 4.63 ± 0.13 s), one was used as a control group continuing training as normal with no systematic acceleration training (CON, N = 13), while the intervention team was matched into two HS subgroups based on their sprint performance. Subgroup one trained with a resistance that induced a 60% velocity decrement from maximal velocity (N = 10, HS60%) and subgroup two used a 50% velocity decrement resistance (N = 9, HS50%) based on individual load-velocity profiles.ResultsBoth heavy resistance subgroups improved significantly all 10-30-m split times (p < 0.05, d = - 1.25; -0.62). Post-hoc analysis showed that HS50% improved significantly more compared to CON in 0-10-m split-time (d = 1.03) and peak power (d = 1.16). Initial maximal theoretical horizontal force capacity (F0) and sprint FV-sprint profile properties showed a significant moderate relationship with F0 adaptation potential (p < 0.05). No significant differences in sprinting kinematics or spatiotemporal variables were observed that remained under the between-session minimal detectable change.ConclusionWith appropriate coaching, heavy resisted sprint training could be one pragmatic option to assist improvements in sprint performance without adverse changes in sprinting kinematics in professional soccer players. Assessing each player's initial individual sprint FV-profile may assist in predicting adaptation potential. More studies are needed that compare heavy resisted sprinting in randomized conditions.

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PPAR? gene variants as predicted performance-enhancing polymorphisms in professional Italian soccer players.

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PPARα gene variants as predicted performance-enhancing polymorphisms in professional Italian soccer players.

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