Ontology highlight
ABSTRACT:
SUBMITTER: Spofford LS
PROVIDER: S-EPMC4266577 | biostudies-literature | 2006 Sep
REPOSITORIES: biostudies-literature
Spofford Laurie S LS Abel Ethan V EV Boisvert-Adamo Karen K Aplin Andrew E AE
The Journal of biological chemistry 20060629 35
D-type cyclins regulate G1 cell cycle progression by enhancing the activities of cyclin-dependent kinases (CDKs), and their expression is frequently altered in malignant cells. We and others have previously shown that cyclin D1 is up-regulated in melanoma cells through adhesion-independent MEK-ERK1/2 signaling initiated by mutant B-RAF. Here, we describe the regulation and role of cyclin D3 in human melanoma cells. Cyclin D3 expression was enhanced in a cell panel of human melanoma cell lines co ...[more]