Electric fingerprint of voltage sensor domains.
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ABSTRACT:
SUBMITTER: Souza CS
PROVIDER: S-EPMC4267369 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Publications
Electric fingerprint of voltage sensor domains.
Souza Caio S CS Amaral Cristiano C Treptow Werner W
Proceedings of the National Academy of Sciences of the United States of America 20141124 49
A dynamic transmembrane voltage field has been suggested as an intrinsic element in voltage sensor (VS) domains. Here, the dynamic field contribution to the VS energetics was analyzed via electrostatic calculations applied to a number of atomistic structures made available recently. We find that the field is largely static along with the molecular motions of the domain, and more importantly, it is minimally modified across VS variants. This finding implies that sensor domains transfer approximat ...[more]
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