Ontology highlight
ABSTRACT:
SUBMITTER: Xing Y
PROVIDER: S-EPMC4267759 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Structure (London, England : 1993) 20080301 3
beta-catenin plays essential roles in cell adhesion and Wnt signaling, while deregulation of beta-catenin is associated with multiple diseases including cancers. Here, we report the crystal structures of full-length zebrafish beta-catenin and a human beta-catenin fragment that contains both the armadillo repeat and the C-terminal domains. Our structures reveal that the N-terminal region of the C-terminal domain, a key component of the C-terminal transactivation domain, forms a long alpha helix t ...[more]