Ontology highlight
ABSTRACT:
SUBMITTER: Priolo C
PROVIDER: S-EPMC4267915 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Priolo Carmen C Pyne Saumyadipta S Rose Joshua J Regan Erzsébet Ravasz ER Zadra Giorgia G Photopoulos Cornelia C Cacciatore Stefano S Schultz Denise D Scaglia Natalia N McDunn Jonathan J De Marzo Angelo M AM Loda Massimo M
Cancer research 20141016 24
Cancer cells may overcome growth factor dependence by deregulating oncogenic and/or tumor-suppressor pathways that affect their metabolism, or by activating metabolic pathways de novo with targeted mutations in critical metabolic enzymes. It is unknown whether human prostate tumors develop a similar metabolic response to different oncogenic drivers or a particular oncogenic event results in its own metabolic reprogramming. Akt and Myc are arguably the most prevalent driving oncogenes in prostate ...[more]