Ontology highlight
ABSTRACT:
SUBMITTER: Hoang KV
PROVIDER: S-EPMC4267924 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Hoang Ky V KV Borteh Hassan M HM Rajaram Murugesan V S MV Peine Kevin J KJ Curry Heather H Collier Michael A MA Homsy Michael L ML Bachelder Eric M EM Gunn John S JS Schlesinger Larry S LS Ainslie Kristy M KM
International journal of pharmaceutics 20141022 1-2
AR-12 has been evaluated in clinical trials as an anti-cancer agent but also has demonstrated host-directed, broad-spectrum clearance of bacteria. We have previously shown that AR-12 has activity in vitro against Salmonella enterica serovar Typhimurium and Francisella species by inducing autophagy and other host immune pathways. AR-12 treatment of S. Typhimurium-infected mice resulted in a 10-fold reduction in bacterial load in the liver and spleen and an increased survival time. However, AR-12 ...[more]