Correlation between decreased CSF ?-synuclein and A????? in Parkinson disease.
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ABSTRACT:
SUBMITTER: Buddhala C
PROVIDER: S-EPMC4268043 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Publications
Correlation between decreased CSF α-synuclein and Aβ₁₋₄₂ in Parkinson disease.
Buddhala Chandana C Campbell Meghan C MC Perlmutter Joel S JS Kotzbauer Paul T PT
Neurobiology of aging 20140804 1
Accumulation of misfolded α-synuclein (α-syn) protein in Lewy bodies and neurites is the cardinal pathologic feature of Parkinson disease (PD), but abnormal deposition of other proteins may also play a role. Cerebrospinal fluid (CSF) levels of proteins known to accumulate in PD may provide insight into disease-associated changes in protein metabolism and their relationship to disease progression. We measured CSF α-syn, amyloid β₁₋₄₂ (Aβ₁₋₄₂), and tau from 77 nondemented PD and 30 control partici ...[more]
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