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Dual-radiolabeled nanoparticle SPECT probes for bioimaging.

ABSTRACT: A gold nanoparticle was radiolabeled with (125)I and (111)In and functionalized with an MMP9-cleavable peptide to form a multispectral SPECT imaging contrast agent. Peptide cleavage from the nanoprobe by MMP9 was observed in vitro, and distinct pharmacokinetic properties of the contrast agent were observed between tumors with high or low MMP9 expression.

SUBMITTER: Black KC 

PROVIDER: S-EPMC4268305 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature

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Dual-radiolabeled nanoparticle SPECT probes for bioimaging.

Black Kvar C L KC   Akers Walter J WJ   Sudlow Gail G   Xu Baogang B   Laforest Richard R   Achilefu Samuel S  

Nanoscale 20150101 2

A gold nanoparticle was radiolabeled with (125)I and (111)In and functionalized with an MMP9-cleavable peptide to form a multispectral SPECT imaging contrast agent. Peptide cleavage from the nanoprobe by MMP9 was observed in vitro, and distinct pharmacokinetic properties of the contrast agent were observed between tumors with high or low MMP9 expression. ...[more]

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