Ontology highlight
ABSTRACT:
SUBMITTER: Ou J
PROVIDER: S-EPMC4268306 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Ou Juanjuan J Miao Hongming H Ma Yinyan Y Guo Feng F Deng Jia J Wei Xing X Zhou Jie J Xie Ganfeng G Shi Hang H Xue Bingzhong B Liang Houjie H Yu Liqing L
Cell reports 20141204 5
How cancer cells shift metabolism to aerobic glycolysis is largely unknown. Here, we show that deficiency of α/β-hydrolase domain-containing 5 (Abhd5), an intracellular lipolytic activator that is also known as comparative gene identification 58 (CGI-58), promotes this metabolic shift and enhances malignancies of colorectal carcinomas (CRCs). Silencing of Abhd5 in normal fibroblasts induces malignant transformation. Intestine-specific knockout of Abhd5 in Apc(Min/+) mice robustly increases tumor ...[more]