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Epigenetic regulation of the NR4A orphan nuclear receptor NOR1 by histone acetylation.

ABSTRACT: The nuclear receptor NOR1 is an immediate-early response gene implicated in the transcriptional control of proliferation. Since the expression level of NOR1 is rapidly induced through cAMP response element binding (CREB) protein-dependent promoter activation, we investigated the contribution of histone acetylation to this transient induction. We demonstrate that NOR1 transcription is induced by histone deacetylase (HDAC) inhibition and by depletion of HDAC1 and HDAC3. HDAC inhibition activated the NOR1 promoter, increased histone acetylation and augmented the recruitment of phosphorylated CREB to the promoter. Furthermore, HDAC inhibition increased Ser133 phosphorylation of CREB and augmented NOR1 protein stability. These data outline previously unrecognized mechanisms of NOR1 regulation and illustrate a key role for histone acetylation in the rapid induction of NOR1.

SUBMITTER: Zhao Y

PROVIDER: S-EPMC4268421 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature

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Epigenetic regulation of the NR4A orphan nuclear receptor NOR1 by histone acetylation.

Zhao Yue Y Nomiyama Takashi T Findeisen Hannes M HM Qing Hua H Aono Jun J Jones Karrie L KL Heywood Elizabeth B EB Bruemmer Dennis D

FEBS letters 20141121 24

The nuclear receptor NOR1 is an immediate-early response gene implicated in the transcriptional control of proliferation. Since the expression level of NOR1 is rapidly induced through cAMP response element binding (CREB) protein-dependent promoter activation, we investigated the contribution of histone acetylation to this transient induction. We demonstrate that NOR1 transcription is induced by histone deacetylase (HDAC) inhibition and by depletion of HDAC1 and HDAC3. HDAC inhibition activated t ...[more]

PMID: 25451221

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Deficiency of the NR4A orphan nuclear receptor NOR1 decreases monocyte adhesion and atherosclerosis.

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