Ontology highlight
ABSTRACT:
SUBMITTER: Zhao Y
PROVIDER: S-EPMC4268421 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Zhao Yue Y Nomiyama Takashi T Findeisen Hannes M HM Qing Hua H Aono Jun J Jones Karrie L KL Heywood Elizabeth B EB Bruemmer Dennis D
FEBS letters 20141121 24
The nuclear receptor NOR1 is an immediate-early response gene implicated in the transcriptional control of proliferation. Since the expression level of NOR1 is rapidly induced through cAMP response element binding (CREB) protein-dependent promoter activation, we investigated the contribution of histone acetylation to this transient induction. We demonstrate that NOR1 transcription is induced by histone deacetylase (HDAC) inhibition and by depletion of HDAC1 and HDAC3. HDAC inhibition activated t ...[more]