Ontology highlight
ABSTRACT:
SUBMITTER: Carrasquillo MM
PROVIDER: S-EPMC4268433 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Carrasquillo Minerva M MM Crook Julia E JE Pedraza Otto O Thomas Colleen S CS Pankratz V Shane VS Allen Mariet M Nguyen Thuy T Malphrus Kimberly G KG Ma Li L Bisceglio Gina D GD Roberts Rosebud O RO Lucas John A JA Smith Glenn E GE Ivnik Robert J RJ Machulda Mary M MM Graff-Radford Neill R NR Petersen Ronald C RC Younkin Steven G SG Ertekin-Taner Nilüfer N
Neurobiology of aging 20140804 1
We tested association of nine late-onset Alzheimer's disease (LOAD) risk variants from genome-wide association studies (GWAS) with memory and progression to mild cognitive impairment (MCI) or LOAD (MCI/LOAD) in older Caucasians, cognitively normal at baseline and longitudinally evaluated at Mayo Clinic Rochester and Jacksonville (n>2000). Each variant was tested both individually and collectively using a weighted risk score. APOE-e4 associated with worse baseline memory and increased decline wit ...[more]