Ontology highlight
ABSTRACT:
SUBMITTER: Hashemi N
PROVIDER: S-EPMC4268487 | biostudies-literature | 2014 Nov-Dec
REPOSITORIES: biostudies-literature
Hashemi Nikroo N Odze Robert D RD McGowan Mary P MP Santos Raul D RD Stroes Erik S G ESG Cohen David E DE
Journal of clinical lipidology 20140815 6
<h4>Background</h4>Mipomersen is an antisense oligonucleotide that inhibits apolipoprotein B synthesis and lowers plasma low-density lipoprotein cholesterol even in the absence of low-density lipoprotein receptor function, presumably from inhibition of hepatic production of triglyceride-rich very low-density lipoprotein particles. By virtue of this mechanism, mipomersen therapy commonly results in the development of hepatic steatosis. Because this is frequently accompanied by alanine aminotransf ...[more]