Ontology highlight
ABSTRACT:
SUBMITTER: Gritsch S
PROVIDER: S-EPMC4268702 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Gritsch Simon S Lu Jianning J Thilemann Sebastian S Wörtge Simone S Möbius Wiebke W Bruttger Julia J Karram Khalad K Ruhwedel Torben T Blanfeld Michaela M Vardeh Daniel D Waisman Ari A Nave Klaus-Armin KA Kuner Rohini R
Nature communications 20141201
Mechanisms underlying central neuropathic pain are poorly understood. Although glial dysfunction has been functionally linked with neuropathic pain, very little is known about modulation of pain by oligodendrocytes. Here we report that genetic ablation of oligodendrocytes rapidly triggers a pattern of sensory changes that closely resemble central neuropathic pain, which are manifest before overt demyelination. Primary oligodendrocyte loss is not associated with autoreactive T- and B-cell infiltr ...[more]