Novel H5 clade 2.3.4.6 viruses with both ?-2,3 and ?-2,6 receptor binding properties may pose a pandemic threat.
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ABSTRACT:
SUBMITTER: Li Q
PROVIDER: S-EPMC4268885 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Novel H5 clade 2.3.4.6 viruses with both α-2,3 and α-2,6 receptor binding properties may pose a pandemic threat.
Li Qunhui Q Wang Xuan X Gu Min M Zhu Jie J Hao Xiaoli X Gao Zhao Z Sun Zhongtao Z Hu Jiao J Hu Shunlin S Wang Xiaoquan X Liu Xiaowen X Liu Xiufan X
Veterinary research 20141217
The emerging H5 clade 2.3.4.6 viruses of different NA subtypes have been detected in different domestic poultry in China. We evaluated the receptor binding property and transmissibility of four novel H5 clade 2.3.4.6 subtype highly pathogenic avian influenza viruses. The results show that these viruses bound to both avian-type (α-2,3) and human-type (α-2,6) receptors. Furthermore, we found that one of these viruses, GS/EC/1112/11, not only replicated but also transmitted efficiently in guinea pi ...[more]
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