Ontology highlight
ABSTRACT:
SUBMITTER: Jego P
PROVIDER: S-EPMC4269735 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Jego Pierrick P Pacheco-Torres Jesús J Araque Alfonso A Canals Santiago S
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20140806 10
Functional magnetic resonance imaging (fMRI) is a fundamental tool to investigate human brain networks. However, the cellular mechanisms underlying fMRI signals are not fully understood. One hypothetical mechanism is the putative vascular control exerted by cytosolic calcium in perivascular astrocytes. We have performed combined fMRI-electrophysiology experiments in mice lacking the inositol 1,4,5-triphosphate-type-2 receptor, with the primary pathway of cytosolic calcium increase eliminated int ...[more]