Ontology highlight
ABSTRACT:
SUBMITTER: Toth P
PROVIDER: S-EPMC4269740 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Toth Peter P Tucsek Zsuzsanna Z Tarantini Stefano S Sosnowska Danuta D Gautam Tripti T Mitschelen Matthew M Koller Akos A Sonntag William E WE Csiszar Anna A Ungvari Zoltan Z
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20140924 12
Aging impairs autoregulatory protection in the brain, exacerbating hypertension-induced cerebromicrovascular injury, neuroinflammation, and development of vascular cognitive impairment. Despite the importance of the age-related decline in circulating insulin-like growth factor-1 (IGF-1) levels in cerebrovascular aging, the effects of IGF-1 deficiency on functional adaptation of cerebral arteries to high blood pressure remain elusive. To determine whether IGF-1 deficiency impairs autoregulatory p ...[more]